Merseyside Police have confirmed they have begun a murder investigation after they were called to an incident earlier this afternoon.
A woman was taken to hospital after an attack at a TUI branch on Chapel Street but has since been pronounced dead.
A 30-year-old man was detained at the scene.
Police confirmed he has now been arrested on suspicion of murder and is currently being held in custody.
A statement from Merseyside Police said: “Merseyside Police can confirm a murder investigation has been launched following an incident in Southport today, Saturday 13th January.
“Officers were contacted at 1.25pm following reports that a 28 year-old woman had been injured at the Tui travel agents on Chapel Street. The woman was taken to hospital where she subsequently died from her injuries.
“The woman’s next of kin have been informed.
“It is believed that the incident was domestic-related.”
A Tui spokeswoman said: “We regret to confirm that a female member of staff at our Southport Tui retail store tragically died in an incident today.
“We send our deepest sympathies to the friends and family of the staff member involved.
“We’re doing everything possible to assist the local police with their investigation and support our customers and staff at this difficult time.”
Photos taken at the scene show the police cordon covering a large section of Chapel Street around the TUI travel agents.
Other nearby shops were been cordoned off, including Game, Vision Express and Carphone Warehouse.
A North West Ambulance Service spokeswoman confirmed they were called to Chapel Street at 1.27pm.
She said: “We got quite a lot of different resources there, we’ve got air ambulances and ambulances and a couple of our advanced paramedics.”
The victim was taken to Southport Hospital by road rather than air ambulance.
Express.co.uk has attempted to contact Merseyside Police on several occasions.
Anyone with information to contact Merseyside Police on 101 quoting log 470 of 13th January or the…